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KMID : 0377219940190010022
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Medical Journal of Chosun Univercity
1994 Volume.19 No. 1 p.22 ~ p.30
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Immunohistochemical Study on the Localization of the Substance P in the Rat Spinal Cord
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Kim Young-Joon
Chung Yoon-Young
Kim Jong-Joong
Moon Jeong-Seok
Chung Ju-Hyun
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Abstract
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An immunohistochemical study was performed using the specific monoclonal antibody against substance P to demonstrate the substance P immunoreactive nerve fibers in the spinal cord of the rats. 1. In the rat spinal cord using immunofluorence method, substance P immunoreactive cell bodies were not found, but their fibers with beaded appearance were observed in all spinal segments. 2. SP immunoreactive nerve fibers were found with the highest concentration especially in the lumbosacral segments. 3. SP immunoreactive nerve fibers could be seen in the Lamina Ⅰ,Ⅱ, X and a great number of substance P immunoreactive nerve fibers appeared in the IML. 4. A smaller number of nerve fibers were observed in the Lamina Ⅸ of ventral region and in the white matter.
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KEYWORD
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Spinal Cord, Substance P(SP), Immunofluorence
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